OnDemand: August 2025 Grand Rounds - Obesity Through the Genetic Lens: A Life Course Perspective

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On-Demand

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Member: $0.00

Non-Member: $50.00

Credit Offered

1 AMA PRA Category 1 Credit

Discover how genetic variation influences body weight across the lifespan—from birth to adulthood. This webinar will focus on the contribution of genetic variation to body weight, highlighting its role in understanding the innate mechanisms that underlie energy homeostasis and its application in precision health strategies.

Breakdown and interpret how different genetic variations influence susceptibility to weight gain

Analyze how genetic influences on brain-regulated hunger, satiety, and reward pathways contribute to obesity risk.

Apply knowledge of genetic influences on appetite regulation and reward pathways to develop personalized patient counseling strategies for obesity risk assessment.

Ruth JF Loos

Professor, University of Copenhagen

Ruth Loos is the Vice Executive Director and Group Leader of the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) at the University of Copenhagen, Denmark. With nearly two decades of experience in the field, she has dedicated her career to understanding the genetic causes of obesity, to gain insights into the biology underlying body weight regulation. She focuses on studying more refined adiposity phenotypes and composite phenotypes to uncover new biological insights that traditional obesity research may have missed. Increasingly, her team also studies the genetic and non-genetic factors contributing to growth and weight gain throughout childhood and adolescence.

The Obesity Society is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The Obesity Society designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

ACCME Activity ID 203263469

Date of Release: September 1, 2025
Date of Termination: December 31, 2027

No commercial support was received for this activity.

Ruth Loos, PhD: Advisor relationship with Novo Nordisk (Pharmaceuticals) Advisor relationship with Eli Lilly (Pharmaceuticals) Speaker relationship with Novo Nordisk (Pharmaceuticals) Speaker relationship with Eli Lilly (Pharmaceuticals) Advisor relationship with Foghorn (Pharmaceuticals)

Monica Agarwal, MD, MEHP, FACE: No relevant financial relationships

No members of the TOS CME Oversight Committee, charged with the resolution of all relevant conflicts of interest, had any relevant financial relationships while serving on the committee.

1. Loos RJF, Yeo GSH. The genetics of obesity: from discovery to biology. Nat Rev Genet. 2022 Feb;23(2):120-133. doi: 10.1038/s41576-021-00414-z. Epub 2021 Sep 23. PMID: 34556834; PMCID: PMC8459824.

2. Loos RJF. Genetic causes of obesity: mapping a path forward. Trends Mol Med. 2025 Apr;31(4):319-325. doi: 10.1016/j.molmed.2025.02.002. Epub 2025 Mar 14. PMID: 40089418.

3. Chami N, Wang Z, Svenstrup V, Diez Obrero V, Hemerich D, Huang Y, Dashti H, Manitta E, Preuss MH, North KE, Holm LA, Fonvig CE, Holm JC, Hansen T, Scheele C, Rauch A, Smit RAJ, Claussnitzer M, Loos RJF. Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities. medRxiv [Preprint]. 2025 Feb 28:2025.02.25.25322830. doi: 10.1101/2025.02.25.25322830. PMID: 40061343; PMCID: PMC11888528.