OnDemand: July 2024 Grand Rounds - Effects of Intentional Weight Loss on Changes in Lean Body Mass and Skeletal Muscle

Data highlighting the effects of weight loss on body composition and loss of lean body mass will be presented and discussed. Dr. Goodpaster will review the effects of exercise and physical activity concomitant with weight loss on insulin resistance and skeletal muscle energy metabolism.

1. After participating in the webinar, learners will be able to describe the effects of intentional weight loss on changes in body composition and on skeletal muscle mass and how exercise impacts these changes.

2. After this webinar, learners will be able to apply what they’ve learned about how weight loss—with or without exercise—affects body composition and metabolism, and they will be able to advise patients on how the interaction of exercise with weight loss can impact muscle mass and energy metabolism.

Dr. Bret H. Goodpaster, PhD

Scientific Director - Senior Investigator

Dr. Goodpaster’s primary research is in the pathophysiology of human obesity, insulin resistance, and diabetes, and to help decipher biological mechanisms underlying the health benefits of exercise. He has received the Nathan Shock Award from the National Institute of Aging in 2008. He is particularly well known for “the athlete’s paradox” which has shifted the paradigm in Type 2 diabetes research to investigate, how and why does fat accumulation in muscle cause insulin resistance in some subjects but not others? Dr. Goodpaster has published over 300 peer-reviewed papers, review articles and book chapters, and his papers have received more than 42,000 citations (h-index 98). He has served on Editorial Boards for Diabetes, the American Journal of Physiology, and the Journals of Gerontology, and served as Associate Editor for both Obesity and Diabetologia. Dr. Goodpaster obtained a B.S. in Biology from Purdue, and after completing a Pre-doctoral Fellowship at Maastricht University in the Netherlands, received his Ph.D. in Human Bioenergetics from Ball State University in 1995.

The Obesity Society is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The Obesity Society designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

ACCME Activity ID 202573211

Date of Release: August 1, 2024
Date of Termination: December 31, 2026

No commercial support was received for this activity.

Bret Goodpaster, PhD: No Relevant Financial Relationships

Monica Agarwal, MD: No Relevant Financial Relationships

Johnny Figueroa, PhD: No Relevant Financial Relationships

Leslie Golden, MD, MPH: No Relevant Financial Relationships

Valentina Ivezaj, PhD: No Relevant Financial Relationships

Aaron Kelly, PhD: No Relevant Financial Relationships

Robert Kushner, MD: Advisor Relationship with Novo Nordisk (Pharmaceuticals), WW (Medical Food and Weight Management*), and Eli Lilly (Pharmaceuticals) Consultant relationship with Altimmune (Pharmaceuticals), Pfizer Inc. (Pharmaceuticals), and Boehringer Ingelheim (Pharmaceuticals)

Magdalena Pasarica, MD, PhD: No Relevant Financial Relationships Jonathan Purnell, MD Consultation Relationship with Novo Nordisk (Pharmaceuticals), Boehringer Ingelheim (Pharmaceuticals), and Luciole (Pharmaceuticals)

Amanda Velazquez, MD: Advisor relationship with WW (Medical Food and Weight Management*) and Intellihealth (Weight Management*) Consultation Relationship with Novo Nordisk (Pharmaceuticals)

Denise Wilfley, PhD: No Relevant Financial Relationships

No members of the TOS CME Oversight Committee, charged with the resolution of all relevant conflicts of interest, had any relevant financial relationships while serving on the committee.

1. Coen PM, Menshikova EV, Distefano G, et al., Goodpaster BH. Exercise and Weight Loss Improve Muscle Mitochondrial Respiration, Lipid Partitioning, and Insulin Sensitivity After Gastric Bypass Surgery. Diabetes. 2015 Nov;64(11):3737-50. doi: 10.2337/db15-0809. Epub 2015 Aug 20. PMID: 26293505; PMCID: PMC4613980.

2. Brennan AM, Standley RA, Anthony SJ, et al., Goodpaster BH. Weight Loss and Exercise Differentially Affect Insulin Sensitivity, Body Composition, Cardiorespiratory Fitness, and Muscle Strength in Older Adults With Obesity: A Randomized Controlled Trial. J Gerontol A Biol Sci Med Sci. 2022 May 5;77(5):1088-1097. doi: 10.1093/gerona/glab240. PMID: 34406407; PMCID: PMC9071425.