OnDemand: March 2024 Grand Rounds - Bariatric Surgery: It’s Not What You Think - Molecular Underpinnings of Surgical Interventions

Bariatric/metabolic surgery remains a potent weapon to create substantial and sustained weight loss but our understanding of how it exerts these effects remains incomplete. This talk will take a deep dive into the molecular underpinnings of how bariatric surgery work and how that informs our understanding of the role the gut plays in energy balance regulation.

1. After participating in the webinar, learners will understand the term “endoplasticity” and how it applies to bariatric surgery.

2. After this webinar, learners will be able to identify multiple ways in which bariatric surgery changes GI function.

Randy J. Seeley

HK Ransom Professor of Surgery, Medicine and Nutritional Sciences

Dr. Randy Seeley is the Henry K. Ransom Endowed Professor of Surgery, Internal Medicine, and Nutritional Sciences at the University of Michigan School of Medicine. He also serves as the director of the NIH-funded Michigan Nutrition Obesity Research Center (MNORC). His scientific work has focused on the role of the gut-brain axis to regulate energy balance, body weight, and circulating fuels. His work has also focused on new treatment strategies for obesity and diabetes. He has published over 400 peer-reviewed articles in Science, Nature, Nature Medicine, Nature Neuroscience, Cell Metabolism, The Journal of Clinical Investigation, and the New England Journal of Medicine. This work has been cited more than 46,000 times, and Dr. Seeley has a Scopus h-index of 105.

The Obesity Society is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The Obesity Society designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

ACCME Activity ID 202573199

Date of Release: April 1, 2024
Date of Termination: December 31, 2026

No commercial support was received for this activity.

Randy Seeley, PhD: Advisor relationship with CinRx (Pharmaceuticals), Crinetics (Pharmaceuticals), Fractyl (Medical Device), and Structure Therapeutics (Pharmaceuticals) Researcher relationship with Amgen (Pharmaceuticals), Astra Zeneca (Pharmaceuticals), Bullfrog AI (Pharmaceuticals), Eli Lilly (Pharmaceuticals), Fractyl (Medical Device), and Glycsend (Pharmaceuticals) Stock Options relationship with Calibrate (Weight Management*) and Rewind (Weight Management*)

Monica Agarwal, MD: No Relevant Financial Relationships

Johnny Figueroa, PhD: No Relevant Financial Relationships

Leslie Golden, MD, MPH: No Relevant Financial Relationships

Valentina Ivezaj, PhD: No Relevant Financial Relationships

Aaron Kelly, PhD: No Relevant Financial Relationships

Robert Kushner, MD: Advisor Relationship with Novo Nordisk (Pharmaceuticals), WW (Medical Food and Weight Management*), and Eli Lilly (Pharmaceuticals) Consultant relationship with Altimmune (Pharmaceuticals), Pfizer Inc. (Pharmaceuticals), and Boehringer Ingelheim (Pharmaceuticals)

Magdalena Pasarica, MD, PhD: No Relevant Financial Relationships Jonathan Purnell, MD Consultation Relationship with Novo Nordisk (Pharmaceuticals), Boehringer Ingelheim (Pharmaceuticals), and Luciole (Pharmaceuticals)

Amanda Velazquez, MD: Advisor relationship with WW (Medical Food and Weight Management*) and Intellihealth (Weight Management*) Consultation Relationship with Novo Nordisk (Pharmaceuticals)

Denise Wilfley, PhD: No Relevant Financial Relationships

No members of the TOS CME Oversight Committee, charged with the resolution of all relevant conflicts of interest, had any relevant financial relationships while serving on the committee.

1. Evers SS, Sandoval DA, Seeley RJ. The Physiology and Molecular Underpinnings of the Effects of Bariatric Surgery on Obesity and Diabetes. Annu Rev Physiol. 2017 Feb 10;79:313-334. doi: 10.1146/annurev-physiol-022516-034423. Epub 2016 Nov 28. PMID: 27912678.

2. Shin JH, Bozadjieva-Kramer N, Shao Y, Lyons-Abbott S, Rupp AC, Sandoval DA, Seeley RJ. The gut peptide Reg3g links the small intestine microbiome to the regulation of energy balance, glucose levels, and gut function. Cell Metab. 2022 Nov 1;34(11):1765-1778.e6. doi: 10.1016/j.cmet.2022.09.024. Epub 2022 Oct 13. PMID: 36240758; PMCID: PMC9633559.

3. Seeley RJ, Chambers AP, Sandoval DA. The role of gut adaptation in the potent effects of multiple bariatric surgeries on obesity and diabetes. Cell Metab. 2015 Mar 3;21(3):369-78. doi: 10.1016/j.cmet.2015.01.001. Epub 2015 Feb 5. PMID: 25662404; PMCID: PMC4351155.